Hello ,I have a question that how I can make one column header different with others?

Many thanks

You can access each header through the Cells collection on the ColumnManagerRow, and then set its properties.   However, if the GridControl.UIStyle property is not set to Classic, you will also need to set the OverrideUIStyle property.

e.g.:

columnManagerRow1.Cells[ "SomeColumn" ].BackColor = Color.Red;